September 10, 2020

The Agency for Healthcare Research and Quality (AHRQ) is interested in receiving public comments on two draft reports, Treatments for Acute Pain: A Systematic Review and Acute Treatments for Episodic Migraine.

• Treatments for Acute Pain: A Systematic Review – This report evaluates the effectiveness and comparative effectiveness of opioid, nonopioid pharmacologic, and nonpharmacologic therapy in patients with specific types of acute pain, including effects on pain, function, quality of life, adverse events, and long-term use of opioids. Overall, AHRQ found that opioids were less effective than nonopioid analgesics for some acute pain conditions and were associated with increased risk of short-term adverse events. Public comments for this report may be submitted here.

   

• Acute Treatments for Episodic Migraine – This report evaluates the effectiveness and comparative effectiveness of pharmacologic and non-pharmacologic therapies for the acute treatment of episodic migraine in adults. Overall, AHRQ asserts that a number of acute treatments for episodic migraine exist with varying degrees of evidence for effectiveness and harms. Use of triptans, NSAIDs, antiemetics, dihydroergotamine, calcitonin gene-related peptide (CGRP) antagonists, and lasmiditan is associated with improved pain and function. Public comment for this report may be submitted here.